I recently purchased a MixPre-6, and also own a 552/680 combo. The MixPre-6 audio quality sounds great, but the ergonomics are obviously cramped compared to the 552. The interface on the MixPre series is well thought out, but once my 552 is set up, I don't find the interface difficult to navigate at all. So, it really comes down to the additional features of the 552 suit your work flow. I have gotten great results working the 552/680 combo, but as a shooter the MixPre's portability suits me better.
BTW, if anyone is looking for a 552 in great condition, I will be putting mine up for sale.